Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomniaBABU RAVULA, Satheesh; JINGHUA YU; HOARE, Samuel R. J et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 421-426, issn 0960-894X, 6 p.Article

Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligandsTRAN, Joe A; TUCCI, Fabio C; ARELLANO, Melissa et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 6, pp 1931-1938, issn 0960-894X, 8 p.Article

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomersZHIQIANG GUO; YONGSHENG CHEN; WADE, Warren et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 10, pp 2519-2522, issn 0960-894X, 4 p.Article

Practical asymmetric synthesis of α-branched 2-piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl iminesWANLONG JIANG; CHEN CHEN; MARINKOVIC, Dragan et al.Journal of organic chemistry. 2005, Vol 70, Num 22, pp 8924-8931, issn 0022-3263, 8 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptorTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3317-3322, issn 0960-894X, 6 p.Article

Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligandsTRAN, Joe A; CHEN, Caroline W; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 3, pp 1124-1130, issn 0960-894X, 7 p.Article

Pyrrolidines as potent functional agonists of the human melanocortin-4 receptorTRAN, Joe A; CHEN, Caroline W; WANLONG JIANG et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 18, pp 5165-5170, issn 0960-894X, 6 p.Article

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl) -6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterizationTUCCI, Fabio C; ZHU, Yun-Fei; REINHART, Greg J et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 4, pp 1169-1178, issn 0022-2623, 10 p.Article

3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-ur acils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptorTUCCI, Fabio C; ZHU, Yun-Fei; TA KUNG CHEN et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 14, pp 3483-3486, issn 0022-2623, 4 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonistsZHIQIANG GUO; ZHU, Yun-Fei; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3311-3315, issn 0960-894X, 5 p.Article

Identification of a novel selective H₁-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomniaMOREE, Wilna J; LI, Bin-Feng; HERNANDEZ, Lisa M et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 19, pp 5874-5878, issn 0960-894X, 5 p.Article

5-Aryluracils as potent GnRH antagonists : Characterization of atropisomersLIREN ZHAO; ZHIQIANG GUO; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3344-3349, issn 0960-894X, 6 p.Article

Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligandsMARINKOVIC, Dragan; TUCCI, Fabio C; TRAN, Joe A et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 17, pp 4817-4822, issn 0960-894X, 6 p.Article

Discovery of Sodium R-(+)-4-{2 [5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1 -yl] -1 -phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorCHEN CHEN; DONGPEI WU; YONGSHENG CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7478-7485, issn 0022-2623, 8 p.Article

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsROWBOTTOM, Martin W; TUCCI, Fabio C; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2269-2274, issn 0960-894X, 6 p.Article

4-{(2R)-[3-aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thieny l)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist-design, synthesis, and characterizationCHEN CHEN; PONTILLO, Joseph; FLECK, Beth A et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 27, pp 6821-6830, issn 0022-2623, 10 p.Article

Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptorPONTILLO, Joseph; TRAN, Joseph A; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 17, pp 4417-4423, issn 0960-894X, 7 p.Article

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activityCHEN CHEN; YONGSHENG CHEN; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3301-3305, issn 0960-894X, 5 p.Article

Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activityTRAN, Joe A; TUCCI, Fabio C; PONTILLO, Joseph et al.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 15, pp 5166-5176, issn 0968-0896, 11 p.Article

Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptorWANLONG JIANG; TUCCI, Fabio C; JOHNS, Michael et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 20, pp 5610-5613, issn 0960-894X, 4 p.Article

Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptorWANLONG JIANG; TRAN, Joe A; FOSTER, Alan C et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 23, pp 6546-6552, issn 0960-894X, 7 p.Article

Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylaminesTRAN, Joe A; PONTILLO, Joseph; FOSTER, Alan C et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 833-837, issn 0960-894X, 5 p.Article

Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5ROWBOTTOM, Martin W; TUCCI, Fabio C; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4967-4973, issn 0960-894X, 7 p.Article

Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZHU, Yun-Fei; GROSS, Timothy D; BONNEVILLE, Anne L et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 11, pp 2023-2026, issn 0022-2623, 4 p.Article

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonistsTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, issn 0960-894X, 5 p.Article